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alpha-conotoxin ImI cystathionine 2-4
Authors
Dekan, Z., Vetter, I., Daly, N., Lewis, R.J., Alewood, P.F., Craik, D.J.
Assembly
alpha-conotoxin ImI Cystathionine 2-4
Entity
1. alpha-conotoxin ImI Cystathionine 2-4 (polymer, Thiol state: all disulfide bound), 12 monomers, 1901.997 Da Detail

GCXSDPRCAW RC


Formula weight
1901.997 Da
Exptl. method
SOLUTION NMR
Data set
assigned_chemical_shifts, conformer_family_coord_set
Chem. Shift Complete
Sequence coverage: 91.7 %, Completeness: 93.4 %, Completeness (bb): 100.0 % Detail

Polymer type: polypeptide(L)

Total1H
All93.4 % (57 of 61)93.4 % (57 of 61)
Backbone100.0 % (21 of 21)100.0 % (21 of 21)
Sidechain90.0 % (36 of 40)90.0 % (36 of 40)
Aromatic50.0 % (3 of 6)50.0 % (3 of 6)
Methyl100.0 % (1 of 1)100.0 % (1 of 1)

1. alpha conotoxin ImI Cystathionine 2-4

GCXSDPRCAW RC

Sample

Solvent system 90% H2O/10% D2O, Temperature 280 K, pH 3


#NameIsotope labelingTypeConcentration
1alpha conotoxin ImI Cystathionine 2-4natural abundance1 mM
2H2Onatural abundance90 %
3D2Onatural abundance10 %

Release date
2011-10-26
Citation
α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure
Dekan, Z., Vetter, I., Daly, N.L., Craik, D.J., Lewis, R.J., Alewood, P.F.
J. Am. Chem. Soc. (2011), 133, 15866-15869, PubMed 21899353 , DOI 10.1021/ja206408q ,
Related entities 1. alpha-conotoxin ImI Cystathionine 2-4, : 1 : 14 : 5 entities Detail
Interaction partners 1. alpha-conotoxin ImI Cystathionine 2-4, : 1 interactors Detail
Experiments performed 3 experiments Detail
Keywords conotoxin ImI, cystathionine, thioether, disulfide