MDM4 binds ligands via an induced fit mechanism in which disordered regions become structured
GSHMDSASRI SPGQINQVRP KLPLLKILHA AGAQGEMFTV KEVMHYLGQY IMVKQLYDQQ EQHMVYCGGD LLGELLGRQS FSVKDPSPLY DMLRKNLVTL AT
Polymer type: polypeptide(L)
Total | 1H | 13C | 15N | |
---|---|---|---|---|
All | 31.9 % (384 of 1205) | 14.4 % (91 of 630) | 48.0 % (224 of 467) | 63.9 % (69 of 108) |
Backbone | 61.0 % (367 of 602) | 37.0 % (77 of 208) | 74.4 % (221 of 297) | 71.1 % (69 of 97) |
Sidechain | 12.8 % (89 of 696) | 3.3 % (14 of 422) | 28.5 % (75 of 263) | 0.0 % (0 of 11) |
Aromatic | 0.0 % (0 of 76) | 0.0 % (0 of 38) | 0.0 % (0 of 38) | |
Methyl | 4.3 % (5 of 116) | 0.0 % (0 of 58) | 8.6 % (5 of 58) |
1. MDM4 N-terminal domain
GSHMDSASRI SPGQINQVRP KLPLLKILHA AGAQGEMFTV KEVMHYLGQY IMVKQLYDQQ EQHMVYCGGD LLGELLGRQS FSVKDPSPLY DMLRKNLVTL ATSolvent system 99% H2O / 1% DMSO, Pressure 1 atm, Temperature 298 K, pH 6.5
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
1 | MDM4 N-terminal domain | [U-100% 13C; U-100% 15N] | 0.1 mM | |
2 | sodium chloride | natural abundance | 100 mM | |
3 | TCEP | natural abundance | 2 mM | |
4 | EDTA | natural abundance | 0.1 mM | |
5 | BisTris | natural abundance | 50 mM | |
6 | sodium azide | natural abundance | 0.1 % | |
7 | H2O | natural abundance | 99 % | |
8 | DMSO | natural abundance | 1 % |