Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6
GHMTGVESFM TKQDTTGKII SIDTSSLRAA GRTGWEDLVR KCIYAFFQPQ GREPSYARQL FQEVMTRGTA SSPSYRFILN DGTMLSAHTR CKLCYPQSPD MQPFIMGIHI IDREHSGLSP QDDTNSGMSI PR
Polymer type: polypeptide(L)
Total | 1H | 13C | 15N | |
---|---|---|---|---|
All | 91.5 % (1720 of 1880) | 92.4 % (907 of 982) | 89.2 % (653 of 732) | 96.4 % (160 of 166) |
Backbone | 93.8 % (900 of 960) | 94.9 % (315 of 332) | 92.0 % (438 of 476) | 96.7 % (147 of 152) |
Sidechain | 90.4 % (966 of 1068) | 91.1 % (592 of 650) | 89.4 % (361 of 404) | 92.9 % (13 of 14) |
Aromatic | 73.9 % (105 of 142) | 87.3 % (62 of 71) | 59.4 % (41 of 69) | 100.0 % (2 of 2) |
Methyl | 97.4 % (148 of 152) | 98.7 % (75 of 76) | 96.1 % (73 of 76) |
1. entity 1
GHMTGVESFM TKQDTTGKII SIDTSSLRAA GRTGWEDLVR KCIYAFFQPQ GREPSYARQL FQEVMTRGTA SSPSYRFILN DGTMLSAHTR CKLCYPQSPD MQPFIMGIHI IDREHSGLSP QDDTNSGMSI PR2. entity 2
GTWIGEDIFP PLLPPTEQDL TKLLLEGQGE SGSolvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 309 K, pH 7.0, Details 50 mM HEPES, 150 mM sodium chloride, 10 % D2O, 1 mM [U-99% 13C; U-99% 15N] STAT6, 90% H2O/10% D2O
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
1 | HEPES | natural abundance | 50 mM | |
2 | sodium chloride | natural abundance | 150 mM | |
3 | D2O | natural abundance | 10 % | |
4 | STAT6 | [U-99% 13C; U-99% 15N] | 1 mM |
Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 309 K, pH 7.0, Details 1 mM [U-99% 13C; U-99% 15N] STAT6, 0.7 mM NCoA1, 50 mM HEPES, 150 mM sodium chloride, 10 % D2O, 90% H2O/10% D2O
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
5 | HEPES | natural abundance | 50 mM | |
6 | sodium chloride | natural abundance | 150 mM | |
7 | D2O | natural abundance | 10 % | |
8 | STAT6 | [U-99% 13C; U-99% 15N] | 1 mM | |
9 | NCoA1 | natural abundance | 0.7 mM |
Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 309 K, pH 7.0, Details 0.7 mM [U-99% 13C; U-99% 15N] NCoA1, 1 mM STAT6, 50 mM HEPES, 150 mM sodium chloride, 10 % D2O, 90% H2O/10% D2O
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
10 | HEPES | natural abundance | 50 mM | |
11 | sodium chloride | natural abundance | 150 mM | |
12 | D2O | natural abundance | 10 % | |
13 | STAT6 | natural abundance | 1 mM | |
14 | NCoA1 | [U-99% 13C; U-99% 15N] | 0.7 mM |
Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 309 K, pH 7.0, Details 1 mM [U-99% 15N] STAT6, 0.7 mM NCoA1, 50 mM HEPES, 150 mM sodium chloride, 10 % D2O, 90% H2O/10% D2O
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
15 | HEPES | natural abundance | 50 mM | |
16 | sodium chloride | natural abundance | 150 mM | |
17 | D2O | natural abundance | 10 % | |
18 | STAT6 | [U-99% 15N] | 1 mM | |
19 | NCoA1 | natural abundance | 0.7 mM |
Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 309 K, pH 7.0, Details 0.7 mM [U-99% 15N] NCoA1, 1 mM STAT6, 50 mM HEPES, 150 mM sodium chloride, 10 % D2O, 90% H2O/10% D2O
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
20 | HEPES | natural abundance | 50 mM | |
21 | sodium chloride | natural abundance | 150 mM | |
22 | D2O | natural abundance | 10 % | |
23 | STAT6 | natural abundance | 1 mM | |
24 | NCoA1 | [U-99% 15N] | 0.7 mM |
Solvent system 90% H2O/10% D2O, Pressure 1 atm, Temperature 309 K, pH 7.0, Details 1 mM [U-99% 15N] STAT6, 50 mM HEPES, 150 mM sodium chloride, 10 % D2O, 90% H2O/10% D2O
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
25 | HEPES | natural abundance | 50 mM | |
26 | sodium chloride | natural abundance | 150 mM | |
27 | D2O | natural abundance | 10 % | |
28 | STAT6 | [U-99% 15N] | 1 mM |
Solvent system 100% D2O, Pressure 1 atm, Temperature 309 K, pH 7.0, Details 1 mM [U-99% 13C; U-99% 15N] STAT6, 0.7 mM NCoA1, 50 mM HEPES, 150 mM sodium chloride, 100 % D2O, 100% D2O
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
29 | HEPES | natural abundance | 50 mM | |
30 | sodium chloride | natural abundance | 150 mM | |
31 | D2O | natural abundance | 100 % | |
32 | STAT6 | [U-99% 13C; U-99% 15N] | 1 mM | |
33 | NCoA1 | natural abundance | 0.7 mM |
Solvent system 100% D2O, Pressure 1 atm, Temperature 309 K, pH 7.0, Details 0.7 mM [U-99% 13C; U-99% 15N] NCoA1, 1 mM STAT6, 50 mM HEPES, 150 mM sodium chloride, 100 % D2O, 100% D2O
# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
34 | HEPES | natural abundance | 50 mM | |
35 | sodium chloride | natural abundance | 150 mM | |
36 | D2O | natural abundance | 100 % | |
37 | STAT6 | natural abundance | 1 mM | |
38 | NCoA1 | [U-99% 13C; U-99% 15N] | 0.7 mM |