BMRB: 4597

Cystic Fibrosis Transmembrane Conductance Regulator: Solution Structures of Peptides Based on the Phe508 Region, the Most Common Site of Disease-Causing DeltaF508 Mutation

Authors

Massiah, M.A., Ko, Y.H., Pedersen, P.L., Mildvan, A.S.

Assembly

Cystic fibrosis transmembrane conductance regulator (CFTR)

Entity

1. Cystic fibrosis transmembrane conductance regulator (CFTR) (polymer, Thiol state: not present), 26 monomers, 3050.486 Da Detail

MPGTIKENII FGVSYDEYRY RSVIKA

Formula weight

3050.486 Da

Source organism

Homo sapiens

Exptl. method

NMR

Refine. method

DISTANCE GEOMETRY

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 96.2 %, Completeness: 88.0 %, Completeness (bb): 94.3 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	88.0 % (146 of 166)	88.0 % (146 of 166)
Backbone	94.3 % (50 of 53)	94.3 % (50 of 53)
Sidechain	85.0 % (96 of 113)	85.0 % (96 of 113)
Aromatic	100.0 % (17 of 17)	100.0 % (17 of 17)
Methyl	92.9 % (13 of 14)	92.9 % (13 of 14)

1. PROTEIN (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR))

MPGTIKENII FGVSYDEYRY RSVIKA

Show sample condition

Sample

Pressure 1 atm, Temperature 298 (±0.5) K, pH 4.0 (±0.1)

#	Name	Isotope labeling	Type	Concentration
1	PROTEIN (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR))			0.0 ~ 0.0 mM
2	H2O			90 %
3	DMSO	[U-2H]		10 %

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Calculated from 10 models in PDB: 1CKY, Strand ID: A Detail

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Release date

2000-12-03

Citation

Cystic fibrosis transmembrane conductance regulator: solution structures of peptides based on the Phe508 region, the most common site of disease-causing DeltaF508 mutation
Massiah, M.A., Ko, Y.H., Pedersen, P.L., Mildvan, A.S.
Biochemistry (1999), 38, 7453-7461, PubMed 10360942 , DOI 10.1021/bi9903603 , Abstract

Entries sharing articles BMRB: 3 entries Detail

Related entities 1. Cystic fibrosis transmembrane conductance regulator (CFTR), : 1 : 29 : 19 : 7 : 180 entities Detail

Interaction partners 1. Cystic fibrosis transmembrane conductance regulator (CFTR), : 29 interactors Detail

Experiments performed 3 experiments Detail