BMRB: 4598

Cystic Fibrosis Transmembrane Conductance Regulator: Solution Structures of Peptides Based on the Phe508 Region, the Most Common Site of Disease-Causing DeltaF508 Mutation

Authors

Massiah, M.A., Ko, Y.H., Pedersen, P.L., Mildvan, A.S.

Assembly

CYSTIC FIBROSIS TRANSMEMBRANE CONDUNTANCE REGULATOR (CFTR)

Entity

1. CYSTIC FIBROSIS TRANSMEMBRANE CONDUNTANCE REGULATOR (CFTR) (polymer, Thiol state: not present), 25 monomers, 2903.313 Da Detail

MPGTIKENII GVSYDEYRYR SVIKA

Formula weight

2903.313 Da

Source organism

Homo sapiens

Exptl. method

NMR

Refine. method

DISTANCE GEOMETRY

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 96.0 %, Completeness: 80.9 %, Completeness (bb): 94.1 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	80.9 % (127 of 157)	80.9 % (127 of 157)
Backbone	94.1 % (48 of 51)	94.1 % (48 of 51)
Sidechain	74.5 % (79 of 106)	74.5 % (79 of 106)
Aromatic	100.0 % (12 of 12)	100.0 % (12 of 12)
Methyl	85.7 % (12 of 14)	85.7 % (12 of 14)

1. PROTEIN (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR))

MPGTIKENII GVSYDEYRYR SVIKA

Show sample condition

Sample

Pressure 1 atm, Temperature 298 (±0.5) K, pH 4.0 (±0.1)

#	Name	Isotope labeling	Type	Concentration
1	PROTEIN (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR))			0.0 ~ 0.0 mM
2	H2O			90 %
3	DMSO	[U-2H]		10 %

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Protein Blocks Logo

Calculated from 13 models in PDB: 1CKZ, Strand ID: A Detail

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Release date

2000-12-03

Citation

Cystic fibrosis transmembrane conductance regulator: solution structures of peptides based on the Phe508 region, the most common site of disease-causing DeltaF508 mutation
Massiah, M.A., Ko, Y.H., Pedersen, P.L., Mildvan, A.S.
Biochemistry (1999), 38, 7453-7461, PubMed 10360942 , DOI 10.1021/bi9903603 , Abstract

Related entities 1. CYSTIC FIBROSIS TRANSMEMBRANE CONDUNTANCE REGULATOR (CFTR), : 1 : 6 : 1 : 78 entities Detail

Interaction partners 1. CYSTIC FIBROSIS TRANSMEMBRANE CONDUNTANCE REGULATOR (CFTR), : 29 interactors Detail

Experiments performed 3 experiments Detail