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Investigation of Penetratin Peptides. Part 1: The Environment Dependent Conformational Properties of Penetratin and two of its Derivatives
Authors
Czajlik, A., Mesko, E., Penke, B., Perczel, A.
Assembly
third helix of Antennapedia homeodomain
Entity
1. third helix of Antennapedia homeodomain (polymer, Thiol state: not present), 16 monomers, 2246.724 Da Detail

RQIKIWFQNR RMKWKK


Formula weight
2246.724 Da
Source organism
Drosophila melanogaster
Exptl. method
NMR
Refine. method
simulated annealing and molecular dynamics
Data set
assigned_chemical_shifts
Chem. Shift Complete1
Sequence coverage: 100.0 %, Completeness: 99.3 %, Completeness (bb): 96.9 % Detail

Polymer type: polypeptide(L)

Total1H
All99.3 % (138 of 139)99.3 % (138 of 139)
Backbone96.9 % (31 of 32)96.9 % (31 of 32)
Sidechain100.0 % (107 of 107)100.0 % (107 of 107)
Aromatic100.0 % (17 of 17)100.0 % (17 of 17)
Methyl100.0 % (4 of 4)100.0 % (4 of 4)

1. third helix of Antennapedia homeodomain

RQIKIWFQNR RMKWKK

Sample

Temperature 300 (±1) K, pH 3 (±0.2)


#NameIsotope labelingTypeConcentration
1third helix of Antennapedia homeodomain1.5 mM
2trifluoroethanol90 %
3water10 %

Chem. Shift Complete2
Sequence coverage: 100.0 %, Completeness: 93.9 %, Completeness (bb): 98.4 % Detail

Polymer type: polypeptide(L)

Total1H
All93.9 % (261 of 278)93.9 % (261 of 278)
Backbone98.4 % (63 of 64)98.4 % (63 of 64)
Sidechain92.5 % (198 of 214)92.5 % (198 of 214)
Aromatic67.6 % (23 of 34)67.6 % (23 of 34)
Methyl100.0 % (8 of 8)100.0 % (8 of 8)

1. third helix of Antennapedia homeodomain

RQIKIWFQNR RMKWKK

Sample

Temperature 300 (±1) K, pH 3 (±0.2)


#NameIsotope labelingTypeConcentration
4third helix of Antennapedia homeodomain1.5 mM
5trifluoroethanol10 %
6water90 %

Protein Blocks Logo
Calculated from 26 models in PDB: 1KZ0, Strand ID: A Detail


Release date
2002-03-28
Citation
Investigation of penetratin peptides. Part 1. The environment dependent conformational properties of penetratin and two of its derivatives
Czajlik, A., Mesko, E., Penke, B., Perczel, A.
J. Pept. Sci. (2002), 8, 151-171, PubMed 11991205 , DOI 10.1002/psc.380 ,
Related entities 1. third helix of Antennapedia homeodomain, : 1 : 81 : 37 : 7 : 67 entities Detail
Interaction partners 1. third helix of Antennapedia homeodomain, : 3 interactors Detail
Experiments performed 3 experiments Detail
Keywords helical structure, trifluoro-ethanol/water mixtures