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Two-Dimensional NMR and Photo-CIDNP Studies of the Insulin Monomer: Assignment of Aromatic Resonances with Application to Protein Folding, Structure, and Dynamics
Authors
Weiss, M.A., Nguyen, D.T., Khait, I., Inouye, K., Frank, B.H., Beckage, M., O'Shea, E., Shoelson, S.E., Karplus, M., Neuringer, L.J.
Assembly
insulin A chain
Entity
1. insulin A chain (polymer), 21 monomers, 2383.696 Da Detail

GIVEQCCTSI CSLYQLENYC N


Formula weight
2383.696 Da
Source organism
Homo sapiens
Exptl. method
NMR
Data set
assigned_chemical_shifts
Chem. Shift Complete
Sequence coverage: 9.5 %, Completeness: 6.7 %, Completeness (bb): 0.0 % Detail

Polymer type: polypeptide(L)

Total1H
All 6.7 % (8 of 120) 6.7 % (8 of 120)
Backbone 0.0 % (0 of 42) 0.0 % (0 of 42)
Sidechain10.3 % (8 of 78)10.3 % (8 of 78)
Aromatic100.0 % (8 of 8)100.0 % (8 of 8)
Methyl 0.0 % (0 of 11) 0.0 % (0 of 11)

1. insulin A chain

GIVEQCCTSI CSLYQLENYC N

Sample

Temperature 303 K, pH 2.2



Release date
1995-07-30
Citation
Two-dimensional NMR and photo-CIDNP studies of the insulin monomer: assignment of aromatic resonances with application to protein folding, structure, and dynamics
Weiss, M.A., Nguyen, D.T., Khait, I., Inouye, K., Frank, B.H., Beckage, M., O'Shea, E., Shoelson, S.E., Karplus, M., Neuringer, L.J.
Biochemistry (1989), 28, 9855-9873, PubMed 2692717 , DOI 10.1021/bi00451a046 ,
Related entities 1. insulin A chain, : 1 : 110 : 9 : 7 : 74 entities Detail
Interaction partners 1. insulin A chain, : 2 interactors Detail
Experiments performed 1 experiments Detail