BMRB: 5869

Solution Conformation of alphaA-Conotoxin EIVA

Authors

Chi, S., Park, K., Suk, J., Olivera, B.M., McIntosh, J.M., Han, K.

Assembly

Alpha-A-conotoxin EIVA

Entity

1. Alpha-A-conotoxin EIVA (polymer, Thiol state: all disulfide bound), 31 monomers, 3101.462 Da Detail

GCCGPYXNAA CHXCGCKVGR XXYCDRXSGG X

Formula weight

3101.462 Da

Entity Connection

disulfide 3 Detail

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ID	Type	Value order	Atom ID 1	Atom ID 2
1	disulfide	sing	1:CYS2:SG	1:CYS16:SG
2	disulfide	sing	1:CYS3:SG	1:CYS11:SG
3	disulfide	sing	1:CYS14:SG	1:CYS24:SG

Source organism

Conus ermineus

Exptl. method

NMR

Refine. method

distance geometry, molecular dynamics

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 80.6 %, Completeness: 99.2 %, Completeness (bb): 98.2 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	99.2 % (123 of 124)	99.2 % (123 of 124)
Backbone	98.2 % (54 of 55)	98.2 % (54 of 55)
Sidechain	100.0 % (69 of 69)	100.0 % (69 of 69)
Aromatic	100.0 % (10 of 10)	100.0 % (10 of 10)
Methyl	100.0 % (4 of 4)	100.0 % (4 of 4)

1. Alpha-A-conotoxin EIVA.

GCCGPYXNAA CHXCGCKVGR XXYCDRXSGG X

Show sample condition

Sample

Pressure 1 atm, Temperature 288 (±1) K, pH 3.6 (±0.1)

#	Name	Isotope labeling	Type	Concentration
1	Alpha-A-conotoxin EIVA.			5 mM

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Protein Blocks Logo

Calculated from 18 models in PDB: 1PQR, Strand ID: A Detail

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Release date

2003-07-13

Citation

Solution conformation of alphaA-conotoxin EIVA, a potent neuromuscular nicotinic acetylcholine receptor antagonist from Conus ermineus
Chi, S., Park, K., Suk, J., Olivera, B.M., McIntosh, J.M., Han, K.
J. Biol. Chem. (2003), 278, 42208-42213, PubMed 12900418 , DOI 10.1074/jbc.M303342200 , Abstract

Entries sharing articles Swiss-Prot: 1 entries Detail

Related entities 1. Alpha-A-conotoxin EIVA, : 1 : 1 : 11 entities Detail

Experiments performed 4 experiments Detail