BMRB: 6063

E6-binding zinc finger (E6apc2)

Authors

Liu, Y., Liu, Z., Androphy, E., Chen, J., Baleja, J.D.

Assembly

E6apc2 peptide

Entity

1. E6apc2 peptide (polymer, Thiol state: not reported), 35 monomers, 4052.687 Da Detail

XYKFACPECP KRFMRSDHLS KHITLHELLG EERRX

Formula weight

4052.687 Da

Source organism

Papillomaviridae

Exptl. method

NMR

Refine. method

simulated annealing

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 94.3 %, Completeness: 67.7 %, Completeness (bb): 98.5 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	67.7 % (149 of 220)	67.7 % (149 of 220)
Backbone	98.5 % (64 of 65)	98.5 % (64 of 65)
Sidechain	54.8 % (85 of 155)	54.8 % (85 of 155)
Aromatic	65.0 % (13 of 20)	65.0 % (13 of 20)
Methyl	83.3 % (10 of 12)	83.3 % (10 of 12)

1. E6apc2

XYKFACPECP KRFMRSDHLS KHITLHELLG EERRX

Show sample condition

Sample

Pressure 1 atm, Temperature 298 K, pH 6.0

#	Name	Isotope labeling	Type	Concentration
1	E6apc2			2.0 mM
2	imidazole	[U-2H]		10 mM
3	ZnSO4			4 mM
4	DTT			1 mM
5	H2O			90 %
6	D2O			10 %

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Calculated from 29 models in PDB: 1RIM, Strand ID: A Detail

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Release date

2005-11-09

Citation

Design and characterization of helical peptides that inhibit the E6 protein of papillomavirus
Liu, Y., Liu, Z., Androphy, E., Chen, J., Baleja, J.D.
Biochemistry (2004), 43, 7421-7431, PubMed 15182185 , DOI 10.1021/bi049552a , Abstract

Entries sharing articles BMRB: 2 entries Detail

Related entities 1. E6apc2 peptide, : 1 : 18 entities Detail

Experiments performed 3 experiments Detail