BMRB: 6892

Structure and influence on stability and activity of the N-terminal propetide part of lung surfactant protein C

Authors

Li, J., Liepinsh, E., Almlen, A., Thyberg, J., Curstedt, T., Jornvall, H., Johansson, J.

Assembly

lung surfactant protein C

Entity

1. lung surfactant protein C (polymer, Thiol state: not present), 31 monomers, 3504.219 Da Detail

SPPDYSAAPR GRFGIPFFPV HLKRLLILLL X

Formula weight

3504.219 Da

Source organism

Homo sapiens

Exptl. method

NMR

Refine. method

torsion angle dynamics

Data set

assigned_chemical_shifts

Chem. Shift Complete

Sequence coverage: 96.8 %, Completeness: 90.9 %, Completeness (bb): 93.0 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	90.9 % (180 of 198)	90.9 % (180 of 198)
Backbone	93.0 % (53 of 57)	93.0 % (53 of 57)
Sidechain	90.1 % (127 of 141)	90.1 % (127 of 141)
Aromatic	57.1 % (12 of 21)	57.1 % (12 of 21)
Methyl	95.0 % (19 of 20)	95.0 % (19 of 20)

1. lung surfactant protein C

SPPDYSAAPR GRFGIPFFPV HLKRLLILLL X

Show sample condition

Sample

Pressure 1 atm, Temperature 297 K, pH 7.5

#	Name	Isotope labeling	Type	Concentration
1	lung surfactant protein C			0.5 mM
2	[2H38]dodecylphosphocholine (DPC)			35 mM
3	sodium phosphate buffer			50 mM
4	H2O			90 %
5	D2O			10 %

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Calculated from 20 models in PDB: 2ESY, Strand ID: A Detail

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Release date

2005-11-28

Citation

Structure and influence on stability and activity of the N-terminal propeptide part of lung surfactant protein C
Li, J., Liepinsh, E., Almlen, A., Thyberg, J., Curstedt, T., Jornvall, H., Johansson, J.
FEBS J. (2006), 273, 926-935, PubMed 16478467 , DOI 10.1111/j.1742-4658.2006.05124.x , Abstract

Related entities 1. lung surfactant protein C, : 1 : 1 entities Detail

Experiments performed 3 experiments Detail