1H and 15N chemical shifts of NH groups in DHFR complexes with brodimoprim analogues 3-5, methotrexate and trimethoprim
TAFLWAQDRD GLIGKDGHLP WHLPDDLHYF RAQTVGKIMV VGRRTYESFP KRPLPERTNV VLTHQEDYQA QGAVVVHDVA AVFAYAKQHP DQELVIAGGA QIFTAFKDDV DTLLVTRLAG SFEGDTKMIP LNWDDFTKVS SRTVEDTNPA LTHTYEVWQK KA
Polymer type: polypeptide(L)
Total | 1H | 15N | |
---|---|---|---|
All | 27.3 % (311 of 1141) | 16.5 % (160 of 971) | 88.8 % (151 of 170) |
Backbone | 63.5 % (305 of 480) | 47.2 % (154 of 326) | 98.1 % (151 of 154) |
Sidechain | 0.9 % (6 of 661) | 0.9 % (6 of 645) | 0.0 % (0 of 16) |
Aromatic | 0.0 % (0 of 102) | 0.0 % (0 of 98) | 0.0 % (0 of 4) |
Methyl | 0.0 % (0 of 97) | 0.0 % (0 of 97) |
1. dihydrofolate reductase
TAFLWAQDRD GLIGKDGHLP WHLPDDLHYF RAQTVGKIMV VGRRTYESFP KRPLPERTNV VLTHQEDYQA QGAVVVHDVA AVFAYAKQHP DQELVIAGGA QIFTAFKDDV DTLLVTRLAG SFEGDTKMIP LNWDDFTKVS SRTVEDTNPA LTHTYEVWQK KA# | Name | Isotope labeling | Type | Concentration |
---|---|---|---|---|
1 | dihydrofolate reductase | 1 mM | ||
2 | potassium phosphate | 50 mM | ||
3 | potassium chloride | 100 mM |