BMRB: 21006

alpha-conotoxin ImI cystathionine 2-4

Authors

Dekan, Z., Vetter, I., Daly, N., Lewis, R.J., Alewood, P.F., Craik, D.J.

Assembly

alpha-conotoxin ImI Cystathionine 2-4

Entity

1. alpha-conotoxin ImI Cystathionine 2-4 (polymer, Thiol state: all disulfide bound), 12 monomers, 1901.997 Da Detail

GCXSDPRCAW RC

Formula weight

1901.997 Da

Exptl. method

solution NMR

Data set

assigned_chemical_shifts, conformer_family_coord_set

Chem. Shift Complete

Sequence coverage: 91.7 %, Completeness: 93.4 %, Completeness (bb): 95.5 % Detail

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Polymer type: polypeptide(L)

	Total	1H
All	93.4 % (57 of 61)	93.4 % (57 of 61)
Backbone	95.5 % (21 of 22)	95.5 % (21 of 22)
Sidechain	92.3 % (36 of 39)	92.3 % (36 of 39)
Aromatic	50.0 % (3 of 6)	50.0 % (3 of 6)
Methyl	100.0 % (1 of 1)	100.0 % (1 of 1)

1. alpha conotoxin ImI Cystathionine 2-4

GCXSDPRCAW RC

Show sample condition

Sample

Solvent system 90% H2O/10% D2O, Temperature 280 K, pH 3

#	Name	Isotope labeling	Type	Concentration
1	alpha conotoxin ImI Cystathionine 2-4	natural abundance		1 mM
2	H2O	natural abundance		90 %
3	D2O	natural abundance		10 %

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Release date

2011-10-26

Citation

α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure
Dekan, Z., Vetter, I., Daly, N.L., Craik, D.J., Lewis, R.J., Alewood, P.F.
J. Am. Chem. Soc. (2011), 133, 15866-15869, PubMed 21899353 , DOI 10.1021/ja206408q , Abstract

Related entities 1. alpha-conotoxin ImI Cystathionine 2-4, : 1 : 14 : 7 entities Detail

Interaction partners 1. alpha-conotoxin ImI Cystathionine 2-4, : 1 interactors Detail

Experiments performed 3 experiments Detail

Chemical shift validation 3 contents Detail