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Found 1 Document (0.278 seconds) for PDB ID: 1018

BMRB: 21018

Compstatin 10
Authors
Qu, H., Ricklin, D., Bai, H., Chen, H., Reis, E., Maciejewski, M., Tzekou, A., DeAngelis, R., Resuello, R., Lupu, F., Barlow, P., Lambris, J.
Assembly
Compstatin 10
Entity
1. Compstatin 10 (polymer, Thiol state: all disulfide bound), 15 monomers, 1582.828 Da Detail

XICVXQDWXA HRCIX


Formula weight
1582.828 Da
Entity Connection
disulfide 1 Detail
IDTypeValue orderAtom ID 1Atom ID 2
1disulfidesing1:CYS3:SG1:CYS13:SG

Exptl. method
solution NMR
Data set
assigned_chemical_shifts
Chem. Shift Complete
Sequence coverage: 73.3 %, Completeness: 92.5 %, Completeness (bb): 90.9 % Detail
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Polymer type: polypeptide(L)

Total1H
All92.5 % (62 of 67)92.5 % (62 of 67)
Backbone90.9 % (20 of 22)90.9 % (20 of 22)
Sidechain93.3 % (42 of 45)93.3 % (42 of 45)
Aromatic87.5 % (7 of 8)87.5 % (7 of 8)
Methyl85.7 % (6 of 7)85.7 % (6 of 7)

1. Compstatin 10

XICVXQDWXA HRCIX

Show sample condition
Sample

Solvent system 90% H2O/10% D2O, Temperature 288 K, pH 6.0


#NameIsotope labelingTypeConcentration
1Compstatin 10natural abundanceprotein5 mM
2Acetate[U-100% 2H]5 mM
3H2Osolvent90 %
4D2Osolvent10 %

Release date
2012-11-01
Citation
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties
Qu, H., Ricklin, D., Bai, H., Chen, H., Reis, E., Maciejewski, M., Tzekou, A., DeAngelis, R., Resuello, R., Lupu, F., Barlow, P., Lambris, J.
Immunobiology (2013), 218, 496-505, PubMed 22795972 , DOI 10.1016/j.imbio.2012.06.003 ,
Related entities 1. Compstatin 10, : 3 entities Detail
More details for 3 related entities
Experiments performed 3 experiments Detail
Chemical shift validation 3 contents Detail
Keywords Compstatin, NMR, peptide, synthetic